Vazquez-Garcia Lab

Massachusetts General Hospital | Harvard Medical School | Broad Institute of MIT and Harvard

Our lab is interested in studying the mechanisms of spatio-temporal tumor evolution, progression and therapy response. Our current research focuses on scalable inference methods and modeling of single-cell genomic and in situ imaging data to study the co-evolution of the tumor and immune ecosystem.

We are recruiting! Find out more about joining the lab.

news

Oct 14, 2026 Our team is headed to the Krantz Family Center for Cancer Research Annual Retreat in Falmouth, MA!
Oct 10, 2026 Congratulations to Vrishank Chandrasekhar on organizing the MIT Undergraduate Research Technology Conference (URTC 2026), a fantastic showcase of undergraduate research. Ignacio gave the closing keynote.
Oct 02, 2026 The inaugural New England Computational Biology Symposium (NECB 2026) was a great success — thanks to everyone who joined us at Microsoft Research New England! Kit Gallagher and Curie Cha presented posters. Photos from the symposium are now online.
Sep 18, 2026 Our lab has been awarded a 2026 Mass General Brigham Pilot Funding Award!
Sep 01, 2026 Our lab has been selected for Anthropic’s AI for Science program!

selected publications

  1. mcpherson2025ongoing.png
    Ongoing genome doubling shapes evolvability and immunity in ovarian cancer
    Andrew W. McPherson*, Ignacio Vazquez-Garcia*, Matthew A. Myers*, Duaa H. Al-Rawi*, Matthew Zatzman*, Adam C. Weiner, Samuel S. Freeman, Neeman Mohibullah, Gryte Satas, Marc J. Williams, Nicholas Ceglia, Danguolė Norkūnaitė, Allen W. Zhang, Jun Li, Jamie L.P. Lim, Michelle Wu, Seongmin Choi, Eliyahu Havasov, Diljot Grewal, Hongyu Shi, Minsoo Kim, Roland F. Schwarz, Tom L. Kaufmann, Khanh N. Dinh, Florian Uhlitz, Julie Tran, Yushi Wu, Ruchi Patel, Satish Ramakrishnan, DooA Kim, Justin Clarke, Hunter Green, Emily Ali, Melody DiBona, Nancy Varice, Ritika Kundra, Vance Broach, Ginger J. Gardner, Kara Long Roche, Yukio Sonoda, Oliver Zivanovic, Sarah H. Kim, Rachel N. Grisham, Ying L. Liu, Agnes Viale, Nicole Rusk, Yulia Lakhman, Lora H. Ellenson, Simon Tavaré, Samuel AJR Aparicio, Dennis S. Chi, Carol Aghajanian, Nadeem R. Abu-Rustum, Claire F. Friedman, Dmitriy Zamarin, Britta Weigelt, Samuel F. Bakhoum, and Sohrab P. Shah
    Nature, 2025
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  2. williams2025tracking.png
    Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA
    Marc J. Williams#, Ignacio Vazquez-Garcia, Grittney Tam, Michelle Wu, Nancy Varice, Eliyahu Havasov, Hongyu Shi, Duaa H. Al-Rawi, Gryte Satas, Hannah J. Lees, Jake June-Koo Lee, Matthew A. Myers, Matthew Zatzman, Nicole Rusk, Emily Ali, Ronak H. Shah, Michael F. Berger, Neeman Mohibullah, Yulia Lakhman, Dennis S. Chi, Nadeem R. Abu-Rustum, Carol Aghajanian, Andrew McPherson, Dmitriy Zamarin, Brian Loomis, Britta Weigelt, Claire F. Friedman, and Sohrab P. Shah#
    Nature, 2025
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  3. vazquez2022ovarian.png
    Ovarian cancer mutational processes drive site-specific immune evasion
    Ignacio Vazquez-Garcia*, Florian Uhlitz*, Nicholas Ceglia, Jamie LP Lim, Michelle Wu, Neeman Mohibullah, Juliana Niyazov, Arvin Eric B Ruiz, Kevin M Boehm, Viktoria Bojilova, and  others
    Nature, 2022
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  4. funnell2022single.png
    Single-cell genomic variation induced by mutational processes in cancer
    Tyler Funnell*, Ciara H O’Flanagan*, Marc J Williams*, Andrew McPherson, Steven McKinney, Farhia Kabeer, Hakwoo Lee, Sohrab Salehi, Ignacio Vazquez-Garcia, Hongyu Shi, and  others
    Nature, 2022
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  5. vazquez2017clonal.png
    Clonal heterogeneity influences the fate of new adaptive mutations
    Ignacio Vazquez-Garcia#, Francisco Salinas, Jing Li, Andrej Fischer, Benjamin Barré, Johan Hallin, Anders Bergström, Elisa Alonso-Perez, Jonas Warringer, Ville Mustonen#, and Gianni Liti#
    Cell Reports, 2017
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