Vazquez-Garcia Lab

Massachusetts General Hospital | Harvard Medical School | Broad Institute of MIT and Harvard

Our lab is interested in studying the mechanisms of spatio-temporal tumor evolution, progression and therapy response. Our current research focuses on scalable inference methods and modeling of single-cell genomic and in situ imaging data to study the co-evolution of the tumor and immune ecosystem.

We are recruiting! Find out more about joining the lab.

news

Mar 05, 2025 Ignacio will be attending the 2025 Cancer Grand Challenges Summit in Boston.
Jan 06, 2025 Our lab is now open! 🎉
Mar 14, 2024 Ignacio has been selected to attend the Irving Cancer Immunology Symposium in Boston on June 24-27, 2024!
Jan 29, 2024 Ignacio has been selected for the AACR NextGen Stars program. As part of this he will be giving a talk at the AACR Annual Meeting in San Diego on April 5-10, 2024.
Oct 15, 2023 Next summer Ignacio will be chairing the 2024 GRS Single-Cell Cancer Biology meeting together with Maren Pein (UC Irvine). It will precede the 2024 GRC Single-Cell Cancer Biology meeting chaired by Mario Suvà (MGH) and Sohrab Shah (MSKCC). Applications are now open!

selected publications

  1. mcpherson2024ongoing.png
    Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer
    Andrew W. McPherson, Ignacio Vazquez-Garcia, Matthew A. Myers, Matthew Zatzman, Duaa H. Al-Rawi, Adam C. Weiner, Samuel S. Freeman, Neeman Mohibullah, Gryte Satas, Marc J. Williams, Nicholas Ceglia, Allen W. Zhang, Jun Li, Jamie L.P. Lim, Michelle Wu, Seongmin Choi, Eliyahu Havasov, Diljot Grewal, Hongyu Shi, Minsoo Kim, Roland F. Schwarz, Tom L. Kaufmann, Khanh N. Dinh, Florian Uhlitz, Julie Tran, Yushi Wu, Ruchi Patel, Satish Ramakrishnan, DooA Kim, Justin Clarke, Hunter Green, Emily Ali, Melody DiBona, Nancy Varice, Ritika Kundra, Vance Broach, Ginger J. Gardner, Kara Long Roche, Yukio Sonoda, Oliver Zivanovic, Sarah H. Kim, Rachel N. Grisham, Ying L. Liu, Agnes Viale, Nicole Rusk, Yulia Lakhman, Lora H. Ellenson, Simon Tavare, Samuel AJR Aparicio, Dennis S. Chi, Carol Aghajanian, Nadeem R. Abu-Rustum, Claire F. Friedman, Samuel F. Bakhoum, Dmitriy Zamarin, Britta Weigelt, and Sohrab P. Shah
    bioRxiv, 2024
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  2. williams2024tracking.png
    Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNA
    Marc J. Williams, Ignacio Vazquez-Garcia, Grittney Tam, Michelle Wu, Nancy Varice, Eliyahu Havasov, Hongyu Shi, Gryte Satas, Hannah J. Lees, Jake Lee, Matthew A. Myers, Matthew Zatzman, Nicole Rusk, Emily Ali, Ronak H. Shah, Michael F. Berger, Neeman Mohibullah, Yulia Lakhman, Dennis S. Chi, Nadeem R. Abu-Rustum, Carol Aghajanian, Andrew McPherson, Dmitriy Zamarin, Brian Loomis, Britta Weigelt, Claire F. Friedman, and Sohrab P. Shah
    bioRxiv, 2024
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  3. vazquez2022ovarian.png
    Ovarian cancer mutational processes drive site-specific immune evasion
    Ignacio Vazquez-Garcia, Florian Uhlitz, Nicholas Ceglia, Jamie LP Lim, Michelle Wu, Neeman Mohibullah, Juliana Niyazov, Arvin Eric B Ruiz, Kevin M Boehm, Viktoria Bojilova, and  others
    Nature, 2022
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  4. funnell2022single.png
    Single-cell genomic variation induced by mutational processes in cancer
    Tyler Funnell, Ciara H O’Flanagan, Marc J Williams, Andrew McPherson, Steven McKinney, Farhia Kabeer, Hakwoo Lee, Sohrab Salehi, Ignacio Vazquez-Garcia, Hongyu Shi, and  others
    Nature, 2022
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  5. vazquez2017clonal.png
    Clonal heterogeneity influences the fate of new adaptive mutations
    Ignacio Vazquez-Garcia, Francisco Salinas, Jing Li, Andrej Fischer, Benjamin Barré, Johan Hallin, Anders Bergström, Elisa Alonso-Perez, Jonas Warringer, Ville Mustonen, and  others
    Cell Reports, 2017
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